Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Identifieur interne : 000B71 ( Main/Exploration ); précédent : 000B70; suivant : 000B72Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
Auteurs : Katharina Nimptsch [Allemagne] ; Mingyang Song [États-Unis] ; Krasimira Aleksandrova [Allemagne] ; Michail Katsoulis [Grèce] ; Heinz Freisling [France] ; Mazda Jenab [France] ; Marc J. Gunter [France] ; Konstantinos K. Tsilidis [Royaume-Uni] ; Elisabete Weiderpass [Norvège] ; H Bas Bueno-De-Mesquita [Royaume-Uni] ; Dawn Q. Chong [États-Unis] ; Majken K. Jensen [États-Unis] ; Chunsen Wu [Danemark] ; Kim Overvad [Danemark] ; Tilman Kühn [Allemagne] ; Myrto Barrdahl [Allemagne] ; Olle Melander [Suède] ; Karin Jirström [Suède] ; Petra H. Peeters [Pays-Bas] ; Sabina Sieri [Italie] ; Salvatore Panico [Italie] ; Amanda J. Cross [Royaume-Uni] ; Elio Riboli [Royaume-Uni] ; Bethany Van Guelpen [Suède] ; Robin Myte [Suède] ; José María Huerta [Espagne] ; Miguel Rodriguez-Barranco [Espagne] ; José Ram N Quir S [Espagne] ; Miren Dorronsoro [Espagne] ; Anne Tj Nneland [Danemark] ; Anja Olsen [Danemark] ; Ruth Travis [Royaume-Uni] ; Marie-Christine Boutron-Ruault [France] ; Franck Carbonnel [France] ; Gianluca Severi [France] ; Catalina Bonet [Espagne] ; Domenico Palli [Italie] ; Jürgen Janke [Allemagne] ; Young-Ae Lee [Allemagne] ; Heiner Boeing [Allemagne] ; Edward L. Giovannucci [États-Unis] ; Shuji Ogino [États-Unis] ; Charles S. Fuchs [États-Unis] ; Eric Rimm [États-Unis] ; Kana Wu [États-Unis] ; Andrew T. Chan [États-Unis] ; Tobias Pischon [Allemagne]Source :
- European journal of epidemiology [ 1573-7284 ] ; 2017.
Abstract
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.
DOI: 10.1007/s10654-017-0262-y
PubMed: 28550647
Affiliations:
- Allemagne, Danemark, Espagne, France, Grèce, Italie, Norvège, Pays-Bas, Royaume-Uni, Suède, États-Unis
- Angleterre, Attique (région), Auvergne-Rhône-Alpes, Bade-Wurtemberg, Berlin, Catalogne, Communauté de Madrid, District de Karlsruhe, Grand Londres, Hovedstaden, Lombardie, Massachusetts, Oxfordshire, Rhône-Alpes, Utrecht (province), Île-de-France
- Athènes, Barcelone, Berlin, Copenhague, Heidelberg, Londres, Lyon, Madrid, Milan, Orsay, Oxford, Utrecht
- Université Paris-Sud, Université d'Oxford
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000B81
- to stream PubMed, to step Curation: 000B78
- to stream PubMed, to step Checkpoint: 000B78
- to stream Ncbi, to step Merge: 004879
- to stream Ncbi, to step Curation: 004879
- to stream Ncbi, to step Checkpoint: 004879
- to stream Main, to step Merge: 000B66
- to stream Main, to step Curation: 000B71
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.</title><author><name sortKey="Nimptsch, Katharina" sort="Nimptsch, Katharina" uniqKey="Nimptsch K" first="Katharina" last="Nimptsch">Katharina Nimptsch</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany. katharina.nimptsch@mdc-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Katsoulis, Michail" sort="Katsoulis, Michail" uniqKey="Katsoulis M" first="Michail" last="Katsoulis">Michail Katsoulis</name><affiliation wicri:level="3"><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chong, Dawn Q" sort="Chong, Dawn Q" uniqKey="Chong D" first="Dawn Q" last="Chong">Dawn Q. Chong</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wu, Chunsen" sort="Wu, Chunsen" uniqKey="Wu C" first="Chunsen" last="Wu">Chunsen Wu</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation wicri:level="3"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J" last="Cross">Amanda J. Cross</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Van Guelpen, Bethany" sort="Van Guelpen, Bethany" uniqKey="Van Guelpen B" first="Bethany" last="Van Guelpen">Bethany Van Guelpen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Oncology, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Myte, Robin" sort="Myte, Robin" uniqKey="Myte R" first="Robin" last="Myte">Robin Myte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Oncology, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="José María" last="Huerta">José María Huerta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Barranco, Miguel" sort="Rodriguez Barranco, Miguel" uniqKey="Rodriguez Barranco M" first="Miguel" last="Rodriguez-Barranco">Miguel Rodriguez-Barranco</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Quir S, Jose Ram N" sort="Quir S, Jose Ram N" uniqKey="Quir S J" first="José Ram N" last="Quir S">José Ram N Quir S</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea><wicri:noRegion>Asturias</wicri:noRegion></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="3"><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation wicri:level="3"><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Travis, Ruth" sort="Travis, Ruth" uniqKey="Travis R" first="Ruth" last="Travis">Ruth Travis</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bonet, Catalina" sort="Bonet, Catalina" uniqKey="Bonet C" first="Catalina" last="Bonet">Catalina Bonet</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Research and Prevention Institute (ISPO), Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Research and Prevention Institute (ISPO), Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Janke, Jurgen" sort="Janke, Jurgen" uniqKey="Janke J" first="Jürgen" last="Janke">Jürgen Janke</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation wicri:level="3"><nlm:affiliation>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rimm, Eric" sort="Rimm, Eric" uniqKey="Rimm E" first="Eric" last="Rimm">Eric Rimm</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pischon, Tobias" sort="Pischon, Tobias" uniqKey="Pischon T" first="Tobias" last="Pischon">Tobias Pischon</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28550647</idno><idno type="pmid">28550647</idno><idno type="doi">10.1007/s10654-017-0262-y</idno><idno type="wicri:Area/PubMed/Corpus">000B81</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B81</idno><idno type="wicri:Area/PubMed/Curation">000B78</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B78</idno><idno type="wicri:Area/PubMed/Checkpoint">000B78</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B78</idno><idno type="wicri:Area/Ncbi/Merge">004879</idno><idno type="wicri:Area/Ncbi/Curation">004879</idno><idno type="wicri:Area/Ncbi/Checkpoint">004879</idno><idno type="wicri:Area/Main/Merge">000B66</idno><idno type="wicri:Area/Main/Curation">000B71</idno><idno type="wicri:Area/Main/Exploration">000B71</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.</title><author><name sortKey="Nimptsch, Katharina" sort="Nimptsch, Katharina" uniqKey="Nimptsch K" first="Katharina" last="Nimptsch">Katharina Nimptsch</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany. katharina.nimptsch@mdc-berlin.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><affiliation wicri:level="1"><nlm:affiliation>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Nutrition, Immunity and Metabolism Start-up Lab, Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Katsoulis, Michail" sort="Katsoulis, Michail" uniqKey="Katsoulis M" first="Michail" last="Katsoulis">Michail Katsoulis</name><affiliation wicri:level="3"><nlm:affiliation>Hellenic Health Foundation, Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Hellenic Health Foundation, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation wicri:level="3"><nlm:affiliation>International Agency for Research on Cancer (IARC-WHO), Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer (IARC-WHO), Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation wicri:level="1"><nlm:affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø</wicri:regionArea><wicri:noRegion>Tromsø</wicri:noRegion></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Chong, Dawn Q" sort="Chong, Dawn Q" uniqKey="Chong D" first="Dawn Q" last="Chong">Dawn Q. Chong</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wu, Chunsen" sort="Wu, Chunsen" uniqKey="Wu C" first="Chunsen" last="Wu">Chunsen Wu</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation wicri:level="1"><nlm:affiliation>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus</wicri:regionArea><wicri:noRegion>Aarhus</wicri:noRegion></affiliation></author><author><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name><affiliation wicri:level="3"><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name><affiliation wicri:level="3"><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation wicri:level="1"><nlm:affiliation>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples</wicri:regionArea><wicri:noRegion>Naples</wicri:noRegion></affiliation></author><author><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J" last="Cross">Amanda J. Cross</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Van Guelpen, Bethany" sort="Van Guelpen, Bethany" uniqKey="Van Guelpen B" first="Bethany" last="Van Guelpen">Bethany Van Guelpen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Oncology, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Myte, Robin" sort="Myte, Robin" uniqKey="Myte R" first="Robin" last="Myte">Robin Myte</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Radiation Sciences, Oncology, Umeå University, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="José María" last="Huerta">José María Huerta</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia</wicri:regionArea><wicri:noRegion>Murcia</wicri:noRegion></affiliation></author><author><name sortKey="Rodriguez Barranco, Miguel" sort="Rodriguez Barranco, Miguel" uniqKey="Rodriguez Barranco M" first="Miguel" last="Rodriguez-Barranco">Miguel Rodriguez-Barranco</name><affiliation wicri:level="3"><nlm:affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER Epidemiología y Salud Pública (CIBERESP), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Quir S, Jose Ram N" sort="Quir S, Jose Ram N" uniqKey="Quir S J" first="José Ram N" last="Quir S">José Ram N Quir S</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Directorate, Asturias, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Directorate, Asturias</wicri:regionArea><wicri:noRegion>Asturias</wicri:noRegion></affiliation></author><author><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><affiliation wicri:level="1"><nlm:affiliation>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Public Health Direction and Biodonostia Research Institute- Ciberesp, Basque Regional Health Department, San Sebastian</wicri:regionArea><wicri:noRegion>San Sebastian</wicri:noRegion></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation wicri:level="3"><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><affiliation wicri:level="3"><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation><country xml:lang="fr">Danemark</country><wicri:regionArea>Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Travis, Ruth" sort="Travis, Ruth" uniqKey="Travis R" first="Ruth" last="Travis">Ruth Travis</name><affiliation wicri:level="4"><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation wicri:level="4"><nlm:affiliation>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Université Paris-Sud, UVSQ, CESP, INSERM, Université Paris-Saclay, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><orgName type="university">Université Paris-Sud</orgName><placeName><settlement type="city">Orsay</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Bonet, Catalina" sort="Bonet, Catalina" uniqKey="Bonet C" first="Catalina" last="Bonet">Catalina Bonet</name><affiliation wicri:level="3"><nlm:affiliation>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Research and Prevention Institute (ISPO), Florence, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Cancer Research and Prevention Institute (ISPO), Florence</wicri:regionArea><wicri:noRegion>Florence</wicri:noRegion></affiliation></author><author><name sortKey="Janke, Jurgen" sort="Janke, Jurgen" uniqKey="Janke J" first="Jürgen" last="Janke">Jürgen Janke</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><affiliation wicri:level="3"><nlm:affiliation>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Genetics of Allergic Disease Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Nuthetal</wicri:regionArea><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion><wicri:noRegion>Nuthetal</wicri:noRegion></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><affiliation wicri:level="2"><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Rimm, Eric" sort="Rimm, Eric" uniqKey="Rimm E" first="Eric" last="Rimm">Eric Rimm</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name><affiliation wicri:level="2"><nlm:affiliation>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation wicri:level="2"><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Pischon, Tobias" sort="Pischon, Tobias" uniqKey="Pischon T" first="Tobias" last="Pischon">Tobias Pischon</name><affiliation wicri:level="3"><nlm:affiliation>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Robert-Rössle-Straße 10, 13125, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">European journal of epidemiology</title><idno type="eISSN">1573-7284</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched controls), the Health Professionals Follow-up Study (HPFS, 231 cases, 230 controls) and the Nurses' Health Study (NHS, 399 cases, 774 controls) with available data on pre-diagnostic adiponectin concentrations and selected single nucleotide polymorphisms in the ADIPOQ gene. We created an ADIPOQ allele score that explained approximately 3% of the interindividual variation in adiponectin concentrations. The ADIPOQ allele score was not associated with risk of colorectal cancer in logistic regression analyses (pooled OR per score-unit unit 0.97, 95% CI 0.91, 1.04). Genetically determined twofold higher adiponectin was not significantly associated with risk of colorectal cancer using the ADIPOQ allele score as instrumental variable (pooled OR 0.73, 95% CI 0.40, 1.34). In a summary instrumental variable analysis (based on previously published data) with higher statistical power, no association between genetically determined twofold higher adiponectin and risk of colorectal cancer was observed (0.99, 95% CI 0.93, 1.06 in women and 0.94, 95% CI 0.88, 1.01 in men). Thus, our study does not support a causal effect of circulating adiponectin on colorectal cancer risk. Due to the limited genetic determination of adiponectin, larger Mendelian Randomization studies are necessary to clarify whether adiponectin is causally related to lower risk of colorectal cancer.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Attique (région)</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>Catalogne</li><li>Communauté de Madrid</li><li>District de Karlsruhe</li><li>Grand Londres</li><li>Hovedstaden</li><li>Lombardie</li><li>Massachusetts</li><li>Oxfordshire</li><li>Rhône-Alpes</li><li>Utrecht (province)</li><li>Île-de-France</li></region><settlement><li>Athènes</li><li>Barcelone</li><li>Berlin</li><li>Copenhague</li><li>Heidelberg</li><li>Londres</li><li>Lyon</li><li>Madrid</li><li>Milan</li><li>Orsay</li><li>Oxford</li><li>Utrecht</li></settlement><orgName><li>Université Paris-Sud</li><li>Université d'Oxford</li></orgName></list><tree><country name="Allemagne"><region name="Berlin"><name sortKey="Nimptsch, Katharina" sort="Nimptsch, Katharina" uniqKey="Nimptsch K" first="Katharina" last="Nimptsch">Katharina Nimptsch</name></region><name sortKey="Aleksandrova, Krasimira" sort="Aleksandrova, Krasimira" uniqKey="Aleksandrova K" first="Krasimira" last="Aleksandrova">Krasimira Aleksandrova</name><name sortKey="Barrdahl, Myrto" sort="Barrdahl, Myrto" uniqKey="Barrdahl M" first="Myrto" last="Barrdahl">Myrto Barrdahl</name><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><name sortKey="Janke, Jurgen" sort="Janke, Jurgen" uniqKey="Janke J" first="Jürgen" last="Janke">Jürgen Janke</name><name sortKey="Kuhn, Tilman" sort="Kuhn, Tilman" uniqKey="Kuhn T" first="Tilman" last="Kühn">Tilman Kühn</name><name sortKey="Lee, Young Ae" sort="Lee, Young Ae" uniqKey="Lee Y" first="Young-Ae" last="Lee">Young-Ae Lee</name><name sortKey="Pischon, Tobias" sort="Pischon, Tobias" uniqKey="Pischon T" first="Tobias" last="Pischon">Tobias Pischon</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Song, Mingyang" sort="Song, Mingyang" uniqKey="Song M" first="Mingyang" last="Song">Mingyang Song</name></region><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><name sortKey="Chong, Dawn Q" sort="Chong, Dawn Q" uniqKey="Chong D" first="Dawn Q" last="Chong">Dawn Q. Chong</name><name sortKey="Fuchs, Charles S" sort="Fuchs, Charles S" uniqKey="Fuchs C" first="Charles S" last="Fuchs">Charles S. Fuchs</name><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><name sortKey="Jensen, Majken K" sort="Jensen, Majken K" uniqKey="Jensen M" first="Majken K" last="Jensen">Majken K. Jensen</name><name sortKey="Ogino, Shuji" sort="Ogino, Shuji" uniqKey="Ogino S" first="Shuji" last="Ogino">Shuji Ogino</name><name sortKey="Rimm, Eric" sort="Rimm, Eric" uniqKey="Rimm E" first="Eric" last="Rimm">Eric Rimm</name><name sortKey="Wu, Kana" sort="Wu, Kana" uniqKey="Wu K" first="Kana" last="Wu">Kana Wu</name></country><country name="Grèce"><region name="Attique (région)"><name sortKey="Katsoulis, Michail" sort="Katsoulis, Michail" uniqKey="Katsoulis M" first="Michail" last="Katsoulis">Michail Katsoulis</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Freisling, Heinz" sort="Freisling, Heinz" uniqKey="Freisling H" first="Heinz" last="Freisling">Heinz Freisling</name></region><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><name sortKey="Carbonnel, Franck" sort="Carbonnel, Franck" uniqKey="Carbonnel F" first="Franck" last="Carbonnel">Franck Carbonnel</name><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><name sortKey="Jenab, Mazda" sort="Jenab, Mazda" uniqKey="Jenab M" first="Mazda" last="Jenab">Mazda Jenab</name><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tsilidis, Konstantinos K" sort="Tsilidis, Konstantinos K" uniqKey="Tsilidis K" first="Konstantinos K" last="Tsilidis">Konstantinos K. Tsilidis</name></region><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><name sortKey="Cross, Amanda J" sort="Cross, Amanda J" uniqKey="Cross A" first="Amanda J" last="Cross">Amanda J. Cross</name><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><name sortKey="Travis, Ruth" sort="Travis, Ruth" uniqKey="Travis R" first="Ruth" last="Travis">Ruth Travis</name></country><country name="Norvège"><noRegion><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name></noRegion></country><country name="Danemark"><noRegion><name sortKey="Wu, Chunsen" sort="Wu, Chunsen" uniqKey="Wu C" first="Chunsen" last="Wu">Chunsen Wu</name></noRegion><name sortKey="Olsen, Anja" sort="Olsen, Anja" uniqKey="Olsen A" first="Anja" last="Olsen">Anja Olsen</name><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name></country><country name="Suède"><noRegion><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name></noRegion><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><name sortKey="Myte, Robin" sort="Myte, Robin" uniqKey="Myte R" first="Robin" last="Myte">Robin Myte</name><name sortKey="Van Guelpen, Bethany" sort="Van Guelpen, Bethany" uniqKey="Van Guelpen B" first="Bethany" last="Van Guelpen">Bethany Van Guelpen</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="Sieri, Sabina" sort="Sieri, Sabina" uniqKey="Sieri S" first="Sabina" last="Sieri">Sabina Sieri</name></region><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name></country><country name="Espagne"><noRegion><name sortKey="Huerta, Jose Maria" sort="Huerta, Jose Maria" uniqKey="Huerta J" first="José María" last="Huerta">José María Huerta</name></noRegion><name sortKey="Bonet, Catalina" sort="Bonet, Catalina" uniqKey="Bonet C" first="Catalina" last="Bonet">Catalina Bonet</name><name sortKey="Dorronsoro, Miren" sort="Dorronsoro, Miren" uniqKey="Dorronsoro M" first="Miren" last="Dorronsoro">Miren Dorronsoro</name><name sortKey="Quir S, Jose Ram N" sort="Quir S, Jose Ram N" uniqKey="Quir S J" first="José Ram N" last="Quir S">José Ram N Quir S</name><name sortKey="Rodriguez Barranco, Miguel" sort="Rodriguez Barranco, Miguel" uniqKey="Rodriguez Barranco M" first="Miguel" last="Rodriguez-Barranco">Miguel Rodriguez-Barranco</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B71 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B71 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28550647
|texte= Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28550647" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |